Every 8 hours.  You suppose to take it 3 times within 24 hours and it is best to separate in equal time intervals.  8x3=24; hence, you take it every 8 hours.   Example: 6am 2pm 10pm You may adjust as needed, say, by changing all three times:   7am, 3pm, & 11pm.   OR   5am, 1pm, 9pm HTH, Maria