answered question 11/21/2009 Is There A Harmful Drug Interaction If Suboxone Is Mixed With Ecstasy(MDMA)? You can, but you might not get high from the Ecstasy pill depending on if he is made with Heir-on or not. If it is a heir on based Ecstasy, then the Suboxone will block the opioid in the "X" pill and will be a watse of time.