answered 4/25/2009 My Leg Pain Occurs During The Night-starting Usually At The Knee And Radiating Down The Leg To My Foot. If I Change Sides The Pain Will Transfer To The Other Leg After 10 Or 15 Minutes. Sometimes Both Legs Are Involved At The Same Time.? I have a similar problem. My chiropractor says it starts from the calf. He believes that once the calf muscles are loosened up enough, the pain will stop occuring. In the mean time, ask your doctor for Vicadin. It really helps.