JANE GILL answered question 12/6/2008 What Insect Bite Begins As A Boil (With A Small Blister In The Center) And Then Swells And Reddens? It Also Runs And Grows Larger. My son had it, it was a spider bite. You need to get antibiotic for it, keep it clean, and put hot towel to drain the pus - and cover with neospren and a Band-aid.