The specifics will come down to what job you're actually looking for and in what industry, but here are some general tips:
Know what you REALLY want to do.
This is the first step to a dream job, and is easier said than done actually...
You need to find something that meets your monetary requirements, challenges you enough that you don't get bored, offers the potential to progress so you're constantly motivated to aim for bigger and better things, and it also needs to be in an environment you enjoy working in.
Maximize your skills and take out the competition
With any job, it's all about what value you bring.
Maybe you can take a course and undergo some sort of training or research that will make you a tailor fit to the role you're after.
For example, if you wanted to land a job as a social media manager for a cool brand. Even before you approach them for a job, you could test out a few social media campaigns to try and engage a similar target audience or to build up a fanbase similar to the one your target role would involve.
That way, when you go for interview, you'll have first-hand experience, tangible assets you can offer, and a proven system that will make you stand out from the rest!
Be positive and persistent
Rejection comes with the territory. Keep focused and confident, and never give up!